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What is Low-Dose Naltrexone?
Low-dose naltrexone (LDN) is a promising new treatment option for various inflammatory and autoimmune conditions. There is a growing body of evidence that the body’s endorphins play a critical role in immune regulation.
These naturally occurring opioids appear to influence how the immune system functions. When taken at bedtime (usually between 9 and 11 p.m.), LDN temporarily blocks the body’s opioid receptors. This short-term blockade is thought to stimulate a rebound effect, increasing endorphin production and enhancing immune system regulation. Naltrexone is effective in 1.5 mg to 4.5 mg, thus, low doses. If you’re already using other medications, do not hesitate to use our free medication review services.
Naltrexone is a medication that blocks the effects of opioids in the brain. It is approved for treating opioid addiction at a standard dose of 50mg. “Low dose” naltrexone refers to the use of a much lower dosage than that used to treat opioid addiction. Naltrexone at this lower dose (up to 4.5mg in most cases) had its first human trial in 2007. Since then, it has shown promise as a treatment for various medical conditions, including multiple sclerosis, Crohn’s disease, fibromyalgia, and more.
LDN is now being studied for a variety of conditions because it is practical as well as safe. There are rarely any side effects reported in studies to date besides some cases of insomnia. The medication is also relatively inexpensive compared to other drugs used to treat these conditions. The result is a potential therapeutic benefit for various conditions, including:
- Multiple sclerosis
- Crohn’s disease
- Fibromyalgia
- Chronic fatigue syndrome
- Hashimoto’s thyroiditis
- Rheumatoid arthritis
- Psoriasis
- …and more.
Low Dose Naltrexone Benefits
There is growing clinical interest in the benefits of low-dose naltrexone. Reported and studied benefits include:
- Reduced inflammation and pain
- Enhanced immune system balance
- Improved mood and mental clarity
- Fewer side effects than many immunosuppressant drugs
- Affordability and accessibility, especially compared to biologic therapies
Patients and practitioners in Canada are increasingly turning to low-dose naltrexone as an adjunct or alternative therapy. As demand rises, awareness of low dose naltrexone in Canada is growing, with more compounding pharmacies offering it by prescription.
Low Dose Naltrexone Side Effects
LDN is generally considered safe, with a low incidence of side effects. Most reported side effects are mild and temporary, including:
- Insomnia or vivid dreams (especially when starting treatment)
- Headache
- Digestive upset
- Increased energy or restlessness
These symptoms usually resolve within the first few weeks of use. As with any medication, patients should consult a healthcare provider before starting low-dose naltrexone to ensure it’s appropriate for their individual health needs.
Where Can You Get Low Dose Naltrexone In Canada?
Because standard naltrexone tablets (50mg) are too strong for off-label use, low-dose naltrexone must be compounded by a licensed compounding pharmacy. To find out more about low-dose Naltrexone, get in touch with one of our compounding pharmacists at any of our locations.
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